ASU awarded $6.4M grant to test preventive canine cancer vaccineJanuary 8, 2018Arizona State University (ASU) professor Stephen Albert Johnson, Ph.D., has received a $6.4 million grant from the Open Philanthropy Project to support a clinical trial of a vaccine to prevent canine cancer. The trial will involve approximately 800 middle-aged, healthy pet dogs and will test the effects of a multivalent frameshift peptide (FSP) vaccine developed at ASU that has shown promise in mouse studies. Scientists think the vaccine has potential for human use, too. "Our goal has always been that if this is possible, we should at least try it," said Johnston, director of the Biodesign Center for Innovations in Medicine and CEO of Calviri Inc., a cancer vaccine company. "Open Philanthropy was the only organization that responded to support our high-risk project, the biggest cancer intervention trial in dogs ever." Johnston and his team developed the new FSP vaccine over the past 10 years. The vaccine, already tested for efficacy in mice, is shown to be safe in dogs, according to Johnston's research. Cancer is the leading cause of death in pet dogs and their cancers are very similar to their human counterparts. Some breeds have a very high cancer rate, as much as 40 percent. The canine …
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