VPN Plus+ ExclusiveIs immunotherapy the key to wiping out canine cancer?June 24, 2020An intact and functional immune system is essential to protect an organism against invading pathogens and infectious disease. However, the immune system also plays a pivotal role in identifying and eliminating transformed cells that, if left unchecked, would progress to cancer. Clinical evidence of the immune system's ability to control cancer comes from a number of observations in both the veterinary and medical settings. Consider the following examples: Cats receiving chronic immunosuppression following renal transplant have a higher incidence of lymphoma compared with the general feline population1,2 Spontaneous regression of transmissible venereal tumor is associated with an increased proportion of tumor-infiltrating cytotoxic CD8+ T cells3 Canine osteosarcoma patients that develop bacterial infections after limb-sparing surgery experience significantly prolonged survival times.4 The presence of tumor-specific, cytotoxic T cells within tumors, such as ovarian carcinoma, confers a favorable prognosis,5 whereas infiltration with regulatory or suppressor T cells confers a worse prognosis6 These observations, coupled with two decades of experimentation in murine cancer models, indicate that finding ways to initiate, augment, and broaden a patient's antitumor immune response holds promise for the treatment and possible prevention of cancer. Indeed, this is the aim of cancer immunotherapy, and recent advances in this field have …
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Studies supporting canine cancer prevention, treatment get fundingMay 5, 2020The AKC Canine Health Foundation has announced grants totaling more than $902,000 for 12 projects.
Genetic enzymes may point to canine cancer preventionApril 15, 2020Certain dogs may be more susceptible than others to developing environmentally associated cancers.
Man busted for hawking fake canine cancer drugsFebruary 6, 2020A Pennsylvania man is accused of scamming the owners of terminally ill pets out of hundreds of thousands of dollars with the promise of “cancer-curing” drugs.
Noninvasive cancer imaging technique to help in early detectionNovember 21, 2019A new cancer imaging technique is expected to significantly improve the ability to diagnose the disease’s spread to lymph nodes in dogs with head and neck tumors.
Canine cancer screening test in the worksOctober 31, 2019Veterinarians may soon be equipped with a tool that would assist in the early detection of canine cancer.
TGen, Ethos develop diagnosis test for canine lymphomaMay 24, 2019A new test may assist veterinarians in more accurately diagnosing canine lymphoma. Developed by Ethos Veterinary Health, Ethos Discovery, and the Translational Genomics Research Institute (TGen), the test is based on the results of a study that analyzed 180 dogs with cancer. The teams used their test, ePARR, to confirm first whether the dogs in the study had lymphoma and then determined what type they had. Results indicate the test was more than 90 percent accurate among a range of lymphoma sample types. "An ongoing need exists for robust validation of molecular diagnostics in veterinary medicine. This study is an example of exhaustive validation of one such molecular test," says Will Hendricks, PhD, assistant professor in TGen's Integrated Cancer Genomics Division and one of the study's senior coauthors. "Overall, ePARR is more than 90 percent accurate across sample types and diagnostic settings." The researchers say not only could molecular-level investigations into dog DNA improve the health of dogs with cancer, but it could help understand cancer in humans, too.
ASU begins clinical study for cancer-preventing vaccineMay 10, 2019An Arizona State University (ASU) professor has begun a five-year clinical study examining the effectiveness of a cancer-preventing vaccine for dogs. Stephen Johnston, PhD, a scientist, professor at the School of Life Sciences, and director of the Biodesign Center for Innovations in Medicine, developed the vaccine over a span of 12 years. He says his goal is to change the way veterinarians treat cancer by preventing it before it can start. Over the course of the five-year study, 800 dogs will either be given the vaccine or a placebo and will be monitored. The University of Wisconsin (UW) School of Veterinary Medicine, Colorado State University (CSU) and University of California (UC), Davis are also participating in the trial. "We're testing a totally novel way of creating an anticancer immune response," says David Vail, DVM, DACVIM (oncology), professor and board-certified oncologist at the UW School of Veterinary Medicine. "The holy grail would be to prevent cancer as opposed to waiting for it to start and then treating it." The vaccine is designed to target common canine cancers, including lymphoma, osteosarcoma, hemangiosarcoma, and mastocytomas. At the beginning, two sets of vaccines will be given every two weeks and then annually. The …
Omega-3 supplements and hypothyroidism linked to decline of T-zone lymphomaApril 4, 2019A study at Colorado State University (CSU) has found dogs who receive omega-3 fatty acid supplements or have hypothyroidism may be less likely to develop T-zone lymphoma (TZL). The findings come from Morris Animal Foundation-funded researchers who looked at associations of the environment and health history of TZL among golden retrievers. T-zone lymphoma is a type of cancer, which progresses slowly and is usually found in older dogs. It is predominantly found in golden retrievers; however, Anne Avery, DVM, PhD, associate professor in the department of microbiology, immunology, and pathology at CSU, believes the underlying causes of the tumor are shared across breeds. "Although controlled prospective studies would be necessary to firmly establish protection by omega-3 fatty acids, our observations raise the possibility of a simple intervention, which may help reduce the frequency of this disease," Dr. Avery says. "We were also a little surprised to discover defective genes leading to another, seemingly unrelated disorder— hypothyroidism—are more common in dogs who do not develop T-zone lymphoma." More than 350 golden retrievers were used in the study, which looked at health history questionnaires and blood or biological samples. The dogs were divided into two groups. One of the groups …
DogsLife offers financial aid for canine cancer treatmentsMarch 20, 2019A new nonprofit is helping pet owners pay for canine cancer treatments by any board-certified veterinary oncologists in North Texas. The organization, DogsLife, selects recipients through an application and interview process involving the pet's owner and veterinarian, as well as the treating veterinary oncologist. The private charity is primarily supported by donations and all of the funds go directly to providing treatments to the dogs. Sir Desmond, a retired racing Greyhound, was diagnosed with osteosarcoma. As a result, the dog's veterinary oncologist recommended his leg be amputated. The price of surgery and chemotherapy was not in Sir Desmond's owner, Caitlin Schmidt's budget, so she applied for assistance from DogsLife. The charity covered half of the surgery and all of the chemotherapy costs. "I cannot really put into words what the phone call meant to me when I was told DogsLife was providing a grant to help pay for all the overages for Desmond's treatment that I simply could not afford," Schmidt says. "Desmond had his amputation surgery and is beginning his chemotherapy."
