Brennen McKenzie

Antimicrobial stewardship: What it is and why it matters

Antimicrobials have tremendous therapeutic benefits in human and veterinary patients. After vaccination, antibiotics are probably the most important medical intervention of the 20th century in terms of reducing suffering and death. Of course, antimicrobials can also have significant adverse effects. And any use of antimicrobials, including appropriate therapeutic use, creates a selection pressure that can result in emergence of antimicrobial resistance (AMR) or an increase in the abundance of resistant bacteria. Adverse effects and the development of resistance reduce the potential benefits of antibiotics. Antimicrobial stewardship is the concept of using antibiotics in a manner that maximizes their benefits, minimizes risks, and conserves the effectiveness of these important drugs.1 Changing when and how we use antibiotics is the key to achieving these goals. Antimicrobial stewardship involves three general strategies: 1) Preventing infectious disease occurrence 2) Reducing overall antimicrobial use 3) Using antimicrobials in ways that maximize the benefits, minimize the adverse effects, and reduce the development of antibiotic resistance Preventing infections Preventing bacterial infections automatically reduces the need for, and hence the use of, antimicrobials. This involves encouraging clients to provide appropriate husbandry and preventive care, including vaccination, proper nutrition, isolation of sick animals, and other prophylactic measures. Prevention of …