Another Zebra Diagnosis: Feline Pyogenic GranulomaJanuary 7, 2015Originally published in the December 2014 issue of Veterinary Practice News Case Discussion Fonzie, a 12-year-old neutered male domestic shorthair cat, was presented for evaluation of a proliferative, bleeding, friable mass arising from the gingiva and mucosa of the dorsolateral surface of the right caudal mandible. Appetite was normal, but the patient did have a history of occasionally exhibiting abnormal chewing motions. The mass had been present for approximately three months and was removed by Fonzie’s primary care veterinarian approximately one month before presentation to me. Biopsy submitted by the primary care veterinarian revealed ulcerated and inflamed granulation tissue. Although the mass appeared to be completely excised on histopathology, it recurred within a few weeks postoperatively. At the time of presentation to me, the mass was approximately 1.5 mm x 1.0 mm x 0.8 mm, located in the area of a missing right mandibular first molar (tooth 409, Figure 1). John R. Lewis, Northstar Vets Figure 1. Pyogenic granuloma in the area of the missing mandibular first molar tooth of a cat. A dental radiograph of the right caudal mandible revealed no osseous involvement and no evidence of retained roots (Figure 2). No other areas of the …
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Sleepypod Offers to Replace Crash-Damaged Travel GearDecember 23, 2014Sleepypod, whose dog travel harnesses have won top marks, is offering a free replacement or discounted pricing when a pet carrier or safety harness is damaged in a traffic accident. The program extends to competitors’ equipment as well. The burden of proof falls on pet owners, who must provide a police report and photos and answer a questionnaire. Damaged Sleepypod products are eligible for no-charge replacement—other than shipping costs—while owners of other brands may receive 30 percent off the Pasadena, Calif., company’s selection of mobile pet beds, carriers and harnesses. “Sleepypod wants to ensure pet safety after an auto accident,” said co-founder and lead product designer Michael Leung. “The integrity of a pet safety restraint may be compromised during an auto accident, so it is critical to inspect a pet carrier or harness for damage before being reused.” Damage may include anything from broken stitches and zippers to torn webbing. “If the accident is severe enough, webbing could be stretched, and therefore weaken the material,” Leung said. More information about the replacement program, which was announced Dec. 18, is available at www.sleepypod.com/accident-replacement-program. The nonprofit Center for Pet Safety, which conducts crash-testing, has deemed Sleepypod’s Clickit Sport …
Abbott Releases 24-Hour Feline Pain DrugDecember 23, 2014Cats recovering from surgery may rest peacefully overnight with the use of a new 24-hour pain control drug from Abbott Animal Health. The Abbott Park, Ill., veterinary drug maker today announced the launch of Simbadol (buprenorphine injection) across the United States, five months after the medication received Food and Drug Administration approval. Simbadol is indicated for postoperative pain control in cats and is formulated to minimize the need for overnight dosing. The drug is the first and only FDA-approved opioid analgesic for cats to provide 24-hour pain control in a single dose, according to Abbott. The Washington State University College of Veterinary Medicine is among the first users of Simbadol. Tammy Grubb, DVM, Ph.D., an assistant professor of anesthesia and analgesia, called the drug “an important advancement for cats and for veterinarians.” “We can be comfortable that our patients have adequate analgesia, even through the night,” Dr. Grubb said. Available in 10mL multidose vials, Simbadol is distributed by MWI Veterinary Supply, Henry Schein Animal Health and Midwest Veterinary Supply.
Jaguar Seeks Limited Approval of Canine Diarrhea DrugDecember 22, 2014The startup drug company Jaguar Animal Health today reported the filing of its first New Animal Drug Application (NADA) with the U.S. Food and Drug Administration. If approved, the drug Canalevia would be used to treat dogs stricken with watery diarrhea during chemotherapy. Jaguar described Canalevia as a first-in-class anti-secretory agent intended for use in multiple animal species. The NADA filing requests Minor Use/Minor Species (MUMS) status for dogs as the drug undergoes further study. The limited designation would allow Jaguar to distribute Canalevia “before collecting all necessary effectiveness data, but after proving the drug is safe and showing that there is a reasonable expectation of effectiveness,” the San Francisco company stated. The decision to pursue MUMS status followed a meeting Oct. 22 between Jaguar and FDA representatives, according to the company. “[The] approach … will allow us to bring this new tool for management of certain chemotherapy side effects to dogs in need as soon as possible,” Jaguar reported. Canalevia contains crofelemer, an antidiarrheal found in the Croton lechleri tree and used to treat HIV-associated diarrhea in people. Jaguar in September launched its first non-prescription product, Neonorm Calf, for the treatment of watery diarrhea, or scours, in …
Aratana Moves Ahead on 2 Canine DrugsDecember 19, 2014A drug being studied for the treatment of osteoarthritis pain in dogs showed positive results in a pivotal field study, according to the developer, Aratana Therapeutics Inc. The Kansas City, Kan., veterinary drug maker also announced the launch of a pivotal field effectiveness study for a drug formulated to treat post-surgical pain in dogs. The osteoarthritis drug, code-named AT-001, was used in a blinded, placebo-controlled, multicenter dose-ranging study involving 280 client-owned dogs. The dogs, all of whom had osteoarthritis, were split into AT-001 and placebo groups and received daily oral doses for 28 days, Aratana reported Thursday. Validated owner-assessed pain scores showed that AT-001, which uses the compound grapiprant to target the EP4 receptor, demonstrated statistically significant improvements compared with the placebo, Aratana noted. The company expects to win U.S. Food and Drug Administration approval of AT-001 in 2016. “We believe AT-001 has the potential to be an important product in the well-established pain market,” said President and CEO Steven St. Peter, MD. Aratana also reported the initiation of a pivotal field effectiveness study of a drug licensed from Pacira Pharmaceuticals Inc. of Parsippany, N.J. AT-003 is an injectable, extended-release bupivacaine formulated for post-operative pain in dogs. A …
Zoetis Unveils FeLV, FIV Combo TestDecember 18, 2014Veterinary drug maker Zoetis Inc. this week began taking orders for a new test designed to diagnose both feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV). Shipments are scheduled to begin Jan. 5. The Witness test kit uses Rapid Immuno Migration (RIM) technology to detect the presence of FeLV antigen and FIV antibodies within 10 minutes, according to the Florham, Park, N.J., company. No refrigeration or snapping—a common physical step in point-of-care diagnostic tests—is necessary. “Since the Witness FeLV-FIV test kit does not require refrigeration, it is easy to store, does not take up refrigerator space, and veterinarians don’t need to wait for it to come to room temperature to use,” said J. Michael McFarland, DVM, Dipl. ABVP, the group director of Companion Animal Veterinary Operations for Zoetis. The combination test rates at 92.9 percent sensitivity and 96.5 percent specificity for FeLV and 93.8 percent sensitivity and 93.4 percent specificity for FIV, the company added. Feline leukemia virus and feline immunodeficiency virus are potentially fatal. FeLV rates in the United States range from 2 to 4 percent of all cats and up to 13 percent or more of cats that are ill, very young or at high risk …
AKC Foundation Honors 6 Research FundraisersDecember 15, 2014Six organizations that over the past 20 years combined to donate more than $3.3 million to the American Kennel Club’s Canine Health Foundation have been named Distinguished Research Partners. Recognized Dec. 11 during the foundation’s Canine & Cocktails event in Orlando, Fla., were the Orthopedic Foundation for Animals, the Irish Setter Club of America Foundation, the Newfoundland Club of America Charitable Trust, the Collie Health Foundation, the Golden Retriever Foundation and the American Boxer Charitable Foundation. The amounts raised by the groups to assist with canine research ranged from the Irish Setter Club’s $131,100 to the American Boxer foundation’s $1,180,130. “These clubs and organizations are making a lasting impact on canine health,” said Shila Nordone, MS, Ph.D., the Canine Health Foundation’s chief scientific officer. “Their donations … are supporting research that addresses some of the most prominent health concerns for our dogs. We are tackling cancer, subaortic stenosis, hypothyroidism, degenerative myelopathy, epilepsy, bloat and cardiomyopathy. “Together, we are working to provide better treatments and more accurate diagnoses for all dogs.” The Canine Health Foundation, a grant-making institution, will celebrate its 20th anniversary in 2015. The foundation also honored Thomas A. Grabe, publisher of The Canine Chronicle, with …
$500,000 Dog Park Debuts in Prescott, Ariz.December 12, 2014What does $500,000 buy? In Prescott, Ariz., that amount of cash has given the community a renovated dog park done up in a firefighter theme. Prescott’s Willow Creek Dog Park was chosen for a half-million-dollar makeover a year ago when resident Linda Nichols won the annual Beneful Dream Dog Park Contest, a competition sponsored by pet food maker Nestlé Purina PetCare Co. Months of work were unveiled Wednesday as Nichols was joined by project managers Jason Cameron, host of the TV shows “Desperate Landscapes,” “Man Caves” and “Sledgehammer,” and pet expert Arden Moore. Nichols and more than 1,000 other dog owners nationwide entered the contest. Nichols’ winning entry was selected from among 14 finalists after a round of judging and public voting. Moore, whose task was to oversee the project from a dog’s point of view, helped bring to life Nichols’ wish for a firefighter theme. Today dogs can race around a miniature red fire truck, run though giant fire truck tires, rest in a covered firehouse lounge and cool off next to fire hydrant misters. The makeover fixed what Nichols described in her contest video as a “large, fenced dirt field with lots of weeds.” Prescott …
Canine Breed-Specific Considerations for AnesthesiaDecember 8, 2014Originally published in the August 2014 issue of Veterinary Practice News The practice of mating individuals with desirable physical characteristics and/or the ability to excel at performing specific tasks has led to the development of over 170 recognized dog breeds in the United States.1 This large variety of dog breeds translates to a very diverse patient population for veterinarians; one may have to anesthetize a great Dane and Chihuahua in the same day. Owners and dog breeders will often express concern about their particular breeds being sensitive to anesthesia; however, there is only one breed–specific anesthetic sensitivity that is supported by scientific evidence: greyhounds. Even though a particular breed may not have a true anesthetic sensitivity, that breed may still warrant specific anesthetic considerations. By selecting for specific traits in dogs we have inadvertently or purposely created unique anatomic, physiologic and metabolic characteristics that may ultimately affect how a given dog is able respond to general anesthesia. An excellent example of this is English bulldog. Shutterstock Greyhounds (and other sighthounds?) Sensitive to thiopental Prolonged recovery from propofol and other drugs The greyhound is the only breed with a documented breed-specific sensitivity to particular anesthetic drugs. Greyhounds have prolonged …
How To Manage Pain In Off-Label SpeciesDecember 8, 2014Originally published in the November 2014 issue of Veterinary Practice News The cat is the off-label species. About 80 percent of all drugs we use in cats are used off label. That includes lactated Ringer’s solution and prednisolone. Managing chronic pain is an off-label event in the cat as no products are FDA-approved for long-term management of feline pain. The situation is somewhat better for acute or post-op pain, but several very widely used options are also off label. Neither cat owners nor their veterinarians are happy to see a cat in pain. However, finding agents that relieve feline pain can be problematic. Some have side effects, and some work better as part of a multimodal approach. None is effective for all patients so a trial-and-error approach may be needed. How to Recognize Pain In the wild, sick cats are targets for predators, so cats have become experts at masking pain. Therefore, with the aid of cat owners supplying careful observations, veterinarians must ask the right questions to uncover the signs of pain. Important questions include: Unwillingness to jump/play Decreased appetite Inappropriate elimination Repeatedly over-grooming the same location Change in mood Treatment of Acute Pain Acute pain is usually due …
