New CAPC study shows Lyme disease is spreadingMay 7, 2019Research from the Companion Animal Parasite Council (CAPC) indicates seroprevalence of Lyme disease in dogs is not only increasing in the Northeast, where it is considered endemic, but also spreading into areas that were previously thought to not be at risk for this serious, zoonotic tick-borne disease. ("Seroprevalence" in this case refers to the prevalence of dogs exposed to Borrelia burgdorferi, the pathogen responsible for causing Lyme disease in the U.S. based on serologic tests—hereafter referred to as "prevalence.") Study results were published in the December 2018 issue of Environmetrics, the official journal of The International Environmetrics Society (TIES). This milestone study, titled "A Large-scale Spatio-temporal Binomial Regression Model for Estimating Seroprevalence Trends," suggests canine prevalence rates for Lyme disease are rising and that those rates are increasing most in areas where the pathogen has recently encroached. Specifically, exposure in dogs to B. burgdorferi is rising in states not traditionally considered to be areas of high Lyme risk. Significant increases in the percentage of dogs testing positive for exposure have also been seen in areas that have not yet reported significant human incidence. These findings suggest canine Lyme prevalence could serve as an early warning system for changes in …
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Is cranberry effective for treating UTIs?April 29, 2019Like most herbal remedies, cranberry has traditionally been employed for a wide variety of unrelated problems, ranging from diseases of the liver and stomach to blood disorders and even cancer.1 These days, however, it is pretty firmly established in the minds of pet owners—and many veterinary professionals—as useful for urinary tract infections (UTIs). It may be surprising, then, to learn there is little convincing evidence to support the effectiveness of cranberry in preventing or treating UTI. The question of whether cranberries, in some form, have value in treating or preventing UTIs is a pretty old one. In addition to historical claims among herbal medicine practitioners, there are scientific references on the subject going back to the 1960s.2 An early theoretical rationale for using cranberry to treat UTIs was it inhibited bacterial growth by acidifying the urine.3,4 However, later research has not substantiated this theory, and this rationale is no longer commonly used to explain the purported benefits of cranberry in preventing or treating a UTI.1,5 The more popular theory today is compounds in cranberry juice, particularly a group called proanthocyanidins, interfere with the attachment of some bacteria to the bladder mucosa, reducing colonization and the establishment of infection.6,7 This …
Dermatology and nutrition: Beyond food allergyApril 29, 2019 When dogs and cats present with skin disorders, the initial approach is to collect a history, do a physical exam, and then perform diagnostic tests to rule in or rule out common conditions. After establishing a tentative diagnosis, most veterinarians will next consider which medications are most appropriate (e.g. antibiotics, antifungals, parasiticides). It is not as common to consider diet and nutrition as part of the workup and treatment for dermatologic disorders, other than performing elimination diet trials for suspected cutaneous adverse food reaction (food allergy). However, the right diets, nutrients, and sometimes nutritional supplements can have a significant benefit in improving or resolving certain skin disorders. This article highlights some of the options for incorporating nutritional science into the management of dermatologic disorders. Cutaneous adverse food reaction The most common presentation for a dog or cat with cutaneous adverse food reaction (CAFR) is nonseasonal pruritus, although other syndromes such as otitis externa and gastrointestinal (GI) upset may occur.1,2 While some companies offer "food allergy testing" using serum, saliva, or even hair clippings, the only valid diagnostic test is an elimination diet trial. There are a number of veterinary therapeutic diets that can be used for diet trials and …
Mars Petcare introduces new division focusing on collaborationApril 9, 2019Mars Petcare has announced the launch of Kinship, a collaboration platform for start-ups, veterinarians, and industry collaborators that provides them access to data, science, and industry expertise. "We're excited about our new global division, Kinship, becoming a unique collaboration platform for entrepreneurs and innovators to create new products and services delivering on our purpose: a better world for pets," says Mars Petcare president, Poul Weihrauch. "There are extraordinary opportunities in data, science, and connected technology. Match them with the expansive reach, resources, and core capabilities of a global industry leader like Mars, and together we can create a powerful force for transforming pet care." The initiative will focus on three main areas: • Health care: Kinship will look for new ways to provide pet owners with care options that are more accessible, effective, and personalized to fit the needs of their pets. • Nutrition: By working together with its partners, Kinship will find new ways to support pet health through nutrition. • Science: Kinship will work with experts to uncover ways to help change pet care through science by applying new discoveries from microbiome biology to machine learning. "Our ambition for Kinship is to bring together the brightest minds …
Education and awareness are key to preventing dog bitesApril 9, 2019Parents learning canine behavioral cues and teaching them to their children to avoid injuries is one of the ways to prevent dog bites. That's according to Texas Veterinary Medical Association (TVMA), which released several recommendations for parents and veterinarians to help keep children safe. The advice comes during National Dog Bite Prevention week, which runs from April 7 to 13. Parents should also be aware of a dog lifting its lip, panting or yawning inappropriately, cowering, holding its breath, flattening its ears to its head, growling, or snapping. "Many dogs will give a warning or several warnings they are uncomfortable, and a person needs to back off," says Lori Teller, DVM, DABVP, a past TVMA president who is a clinical associate professor at the Texas A&M University College of Veterinary Medicine. "People often miss these signs and think a dog bite occurred out of the blue." The Centers for Disease Control and Prevention (CDC) says 4.7 million dog bites are reported every year. Seventeen percent of them require medical care—half of the victims are children. According to TVMA, it is important to teach children not to approach unknown dogs, but it also warns many dog bites occur when interacting …
University of Minnesota seeks participants for skin disease studyApril 5, 2019University of Minnesota (UMN) College of Veterinary Medicine is looking for candidates to enroll in an allergic skin disease study. The clinical trial will assess the safety and efficacy of a topical gel for dogs with atopic dermatitis (AD), which is a skin condition that causes severe itching and is hard to manage. According to the researchers, many of the current treatments produce unwanted side effects or they do not fully treat the symptoms. The study will last 14 days and will require the participants to visit UMN on day zero, seven, and 14. The dogs' owners will be required to use a topical gel on areas of their pets' skin and keep a medication diary throughout the duration. During the visits, Sheila Torres, DVM, MS, PhD, DACVD, will examine and assess the participants. Blood samples will be taken every visit and urine samples on day zero and 14. There is no cost, and at the end of the study dog owners will be eligible for to a $200 debit card. To participate dogs must: • have a short hair coat; • have red and inflamed skin, especially on their belly and/or paws; • have a …
Omega-3 supplements and hypothyroidism linked to decline of T-zone lymphomaApril 4, 2019A study at Colorado State University (CSU) has found dogs who receive omega-3 fatty acid supplements or have hypothyroidism may be less likely to develop T-zone lymphoma (TZL). The findings come from Morris Animal Foundation-funded researchers who looked at associations of the environment and health history of TZL among golden retrievers. T-zone lymphoma is a type of cancer, which progresses slowly and is usually found in older dogs. It is predominantly found in golden retrievers; however, Anne Avery, DVM, PhD, associate professor in the department of microbiology, immunology, and pathology at CSU, believes the underlying causes of the tumor are shared across breeds. "Although controlled prospective studies would be necessary to firmly establish protection by omega-3 fatty acids, our observations raise the possibility of a simple intervention, which may help reduce the frequency of this disease," Dr. Avery says. "We were also a little surprised to discover defective genes leading to another, seemingly unrelated disorder— hypothyroidism—are more common in dogs who do not develop T-zone lymphoma." More than 350 golden retrievers were used in the study, which looked at health history questionnaires and blood or biological samples. The dogs were divided into two groups. One of the groups …
CVMA and California veterinarians clash over blood banksApril 4, 2019A showdown is brewing between the California Veterinary Medical Association (CVMA) and a group of veterinarians over whether closed-colony blood banks should continue to operate. Known as the California Pet Blood Bank Modernization Act, AB 366 bill is aimed at changing the existing law requiring animal blood banks collect blood exclusively from so-called "closed colonies." Critics say donor animals are confined to cages and kennels for months or years. Instead, the bill looks to allow blood banks to collect animal blood in a community-based, voluntary setting, similar to programs in place in other states. The bill is getting support from 72 veterinarians, including practitioners and medical directors at some of California's largest veterinary hospitals, and faculty and clinicians at the University of California, Davis. "The current situation in California is egregiously unbalanced," they say in a letter to California's assembly agriculture committee. "Hundreds of dogs—including many who have already endured months or years of suffering in the greyhound racing industry—are kept confined for months or years in situations that range from inadequate to appalling. Lack of sufficient oversight and inspection, coupled with a lack of transparency, has resulted in years of suffering by dogs in California's closed colonies. There …
What does 503B compounding mean for the future of veterinary medicine?April 3, 2019Modern compounding—often referred to as 503A—is a niche business, providing patient-specific formulations to satisfy individual needs. Because commercially available drugs are marketed almost exclusively for humans, compounding has become an essential resource for veterinary medicine. Veterinarians often depend on 503A pharmacies to provide preparations at lower concentrations and in more palatable dosage forms to optimize treatment for their patients. However, without proper management and regulations, 503A compounding can potentially be detrimental. Presently, 503A pharmacies are not required to adhere to Current Good Manufacturing Practice (cGMP) objectives put forth by the U.S. Food and Drug Administration (FDA) to ensure pharmaceuticals achieve a specified standard of safety. The quality of products produced in a 503A facility depend on the pharmacy's voluntary conformance with cGMP, which can be substantially cost-prohibitive, requiring anywhere from $50,000 to $100,000-plus of investment for a single formulation. Testing on raw materials and finished products may be performed to an extent depending on the facility, but the data are often incomplete, testing only one or two factors while omitting others that would affect the product's overall quality. The variability of cGMP compliance from pharmacy to pharmacy paves the way for omissions in procedures that can lead to patient harm. …
FDA approves treatment for urinary incontinence in dogsApril 2, 2019PROIN ER, a tablet for the control of urinary incontinence in dogs, has been approved by the U.S. Food and Drug Administration (FDA). The drug treats urethral sphincter hypotonus, which occurs due to a dog's age and weakening muscles in the urethra. PROIN Chewable Tablets have already been approved by the FDA; however, they are to be administered twice a day, whereas PROIN ER is a once-a-day extended-release formulation. The effectiveness of PROIN ER was observed in a clinical study comprising 119 dogs that had been previously diagnosed with urethral sphincter hypotonus and had been taking PROIN Chewable Tablets. The timeline of the clinical study went as follows: • For the first week, the owners documented whether the dog received the PROIN Chewable Tablet doses and noted the number of urinary accidents the dog had; • Dogs were then given PROIN ER for the first 28 days and the owners proceeded to take note of how many accidents occurred in a day; • In the fourth week, the number of urinary accidents was compared to the first week. It was found 75 of the 104 dogs who completed the study had no accidents on either tablet;
